With yesterday's version (also the ones from the days before) I get random lockups after a while. I sometimes let the game run unattended (at +19% speed) for a while, but it crashes (0% CPU) apparently at random intervals. Sometimes after 20 minutes, sometimes after several hours. Win10, 2 CPUs.
The only thing I changed in the config are autosave and no tree & pedes info.
It's 1843 and I run coaches, ships and one train. The only thing I can think of that is probably unusual is that my train line has just a few one-staff cabinets along the way to prevent drive-by-sight driving.
A freeze with 0% CPU utilisation is consistent with a thread deadlock, which is a very difficult fault to trace. However, it would help greatly if you could upload the saved game in which these problems occur.
As a workaround in the meantime, I recommend frequent saving.